Disorders of the Monocyte Macrophage System

Pathophysiological Aspects.- Current View of the Mononuclear Phagocyte System.- The Kinetics of Mononuclear Phagocytes in Man.- Biochemical Properties of Human and Murine Mononuclear Phagocytes and Their Changes on Activation.- Macrophages in the Regulation of Immunity.- The Role of Macrophages as Effector Cells.- The Macrophage as a Cytotoxic Effector Cell.- The Role of Complement in the Function of the Monocyte-Macrophage System.- Macrophage-Dependent Production of Erythropoietin and Colony-Stimulating Factor.- The Relation Between Monocytes and Resident (Tissue) Macrophages.- Development of Exudate-Resident Macrophages in Vivo and in Vitro.- The Monocyte-Macrophage System in Granulomatous Inflammation.- Macrophages in Granulomas: Histochemical Evidence Suggesting Local Control of Heterogeneous Functions.- The Role of Macrophages in Storage Diseases.- Interaction of Lipoproteins with Macrophages.- The Role of Macrophages in Atherosclerosis.- Clinical Syndromes.- Acute Monocytic Leukemias.- Subacute and Chronic Myelomonocytic Leukemia.- Lysosomal Granules in Leukemic Monocytes and Their Relation to Maturation Stages.- Characteristics and Functions of Monocytes and Promonocytes in Monocytic Leukemia.- Chronic Monocytic Leukemias.- Therapy of Acute Monoblastic Leukemia.- Histiocytic Medullary Reticulosis -- Neoplastic or Atypical Inflammatory Process?.- Histiocytic Medullary Reticulosis Re-visited.- Therapy of Malignant Histiocytosis.- Immunohistochemical Marking of Malignant Fibrous Histiocytoma and Malignant Histiocytosis.- Malignant Histiocytic Disorders of the Skin.- Childhood Histiocytosis X, Clinical Aspects and Therapeutic Approaches.- Therapy in Pulmonary Histiocytosis X.- Sinus Histiocytosis with Massive Lymphadenopathy and Epidural Involvement.- FamilialLymphohistiocytosis.- Concluding Remarks: The Pathology of the MMS-Present Knowledge and Future Trends.